Review: Application of Nanoparticles in Urothelial Cancer of the Urinary Bladder
نویسندگان
چکیده
Bladder cancer is a common malignancy of the urinary tract, which generally develops in the epithelial lining of the urinary bladder. The specific course of treatment depends on the stage of bladder cancer; however, therapeutic strategies typically involve intravesical drug delivery to reduce toxicity and increase therapeutic effects. Recently, metallic, polymeric, lipid, and protein nanoparticles have been introduced to aid in the treatment of bladder cancer. Nanoparticles are also commonly used as pharmaceutical carriers to improve interactions between drugs and the urothelium. In this review, we classify the characteristics of bladder cancer and discuss the types of nanoparticles used in various treatment modalities. Finally we summarize the potential applications and benefits of various nanoparticles in intravesical therapy.
منابع مشابه
Review Article: Application of Electrical Impedance Spectroscopy in Bladder Cancer Screening
Introduction Bladder cancer is the most common malignancy in elderly people and most bladder cancers are transitional cell carcinomas (TCC). Bladder pathology is usually investigated visually by cystoscopy and this technique can represent different conditions ranging from simple inflammation to flat CIS. However, biopsies must be taken from the suspected area to obtain diagnostic information. T...
متن کاملHigh-Grade Urothelial Carcinoma of Bladder Transforming to Micropapillary Variant on Follow-Up
Micropapillary variant of urothelial carcinoma (UC) of the bladder is an aggressive tumour, comprising 0.6-6% of all UC. It generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional UC. We report the case of a 58-year-old man who presented with macroscopic haematuria. The patient was diagnosed with high-grade urothelial carcinom...
متن کاملگزارش یک مورد سرطان اوروتلیال پلاسماسیتوئید مثانه
Bladder cancer most commonly exists as an epithelial tumor in which around 90% of cases are transitional cell carcinoma (TCC) with a papillary appearance. The world health organization (WHO) classification defines new histological and molecular variants of urothelial carcinoma in 2004. One of them is plasmacytoid urothelial carcinoma (PUC). Less than 100 cases have been reported in the literatu...
متن کاملDysregulated Expression of Long Intergenic Non-coding RNAs (LincRNAs) in Urothelial Bladder Carcinoma
Long intergenic non-coding RNA (lincRNA) has been introduced as key regulators of diverse biological processes, including transcription, chromatin organization, cell growth and tumorigenesis. With regard to the potential role of lincRNAs in cancer development, one may postulate that differential expression of lincRNAs could be employed as a tool in cancer diagnosis, prognosis, and targeted ther...
متن کاملWhat are the currently available and in development molecular markers for bladder cancer? Will they prove to be useful in the future?
Urothelial carcinoma is the 9(th) most common cancer worldwide. Most urothelial tumors are non-muscle invasive on presentation. However, two-thirds of non-invasive bladder cancers will eventually recur with a 25% risk of progression to muscle-invasive bladder cancer. Tumor stage, histological grade and pathological invasion of blood vessels and lymphatic tissue are the main indicators for uroth...
متن کامل